Resistance by Allostery: A Novel Perspective for Eg5-Targeted Drug Design

Title
Resistance by Allostery: A Novel Perspective for Eg5-Targeted Drug Design
Authors
앰빌리 나스배애님
Keywords
Eg5; Kinesin Spindle Protein; Allostery; anticancer
Issue Date
2013-07
Publisher
Journal of medicinal chemistry
Citation
VOL 56, NO 16, 6314-6316
Abstract
Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made pathbreaking revelations in Eg5 studies and discussed a novel phenomenon “resistance by allostery”, which could have far-reaching consequences from a rational drug design perspective.
URI
http://pubs.kist.re.kr/handle/201004/46243
ISSN
00222623
Appears in Collections:
KIST Publication > Article
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