Prediction of posttreament significant body weight loss and its correlation with disease-free survival in patients with oral squamous cell carcinomas

Title
Prediction of posttreament significant body weight loss and its correlation with disease-free survival in patients with oral squamous cell carcinomas
Authors
Young-Wook ChoJong-Lyel RohJae Hoon JungSung-Bae KimSang-wook LeeSeung-Ho ChoiSoon Yuhl Nam김상윤
Issue Date
2013-04
Publisher
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
Citation
VOL 65, NO 3, 417-423
Abstract
Significant loss of body weight (SLW) by patients treated for squamous cell carcinomas of the oral cavity and oropharynx (OSCC) may affect treatment completion and results. We assessed factors predicting SLW and its correlation with diseasefree survival (DFS) in these patients. We evaluated 226 consecutive patients with previously untreated, operable OSCC whose body weight was recorded before, during, and for up to 1 year after treatment. SLW was defined as ≥10% reduction in pretreatment body weight. Clinicopathologic parameters were compared in patients with and without SLW. Of the 226 patients, 94 (41.6%) experienced SLW and 132 (58.4%) did not. Univariate analyses showed that factors significantly associated with SLW included T3&#8211;4, N+, stage III&#8211;IV, and oropharyngeal tumors, nonsurgical (radiotherapy or chemotherapy) vs. surgical treatment, posttreatment recurrence, histologic differentiation, involved resectionmargin, and number of metastatic lymph nodes (pLNs) ≥ 3 (P < 0.05). Multivariate analyses showed that radiotherapy, recurrence, and number of pLNs were significant independent predictors of SLW (P < 0.005). DFS rate was significantly higher in patients without than with SLW (P < 0.01). OSCC patients with multiple pLNs, those undergoing radiotherapy, and those with posttreatment recurrences may require close nutritional monitoring and support.
URI
http://pubs.kist.re.kr/handle/201004/46255
ISSN
01635581
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KIST Publication > Article
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