Prognostic Value of Preoperative Metabolic Tumor Volume and Total Lesion Glycolysis Measured by 18F-FDG PET/CT in Salivary Gland Carcinomas

Title
Prognostic Value of Preoperative Metabolic Tumor Volume and Total Lesion Glycolysis Measured by 18F-FDG PET/CT in Salivary Gland Carcinomas
Authors
In Sun RyuJae Seung KimJong-Lyel RohJeong Hyun LeeKyung-Ja ChoSeung-Ho ChoiSoon Yuhl Nam김상윤
Keywords
salivary gland carcinomas; 18F-FDG PET/CT; metabolic tumor volume; total lesion glycolysis; prognostic factors
Issue Date
2013-07
Publisher
The Journal of nuclear medicine
Citation
VOL 54, NO 7, 1032-1038
Abstract
Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) from 18F-FDG PET/CT are emerging prognostic biomarkers in various human cancers. This study examined the prognostic value of these metabolic tumor parameters measured by pretreatment 18F-FDG PET/CT in patients with salivary gland carcinomas. Methods: Forty-nine patients with intermediate- or high-grade salivary gland carcinomas who underwent definitive surgery with or without radiotherapy or chemoradiotherapy were evaluated preoperatively by 18F-FDG PET/CT. Maximum standardized uptake values (SUVmax), MTV, and TLG were measured for each patient. Univariate and multivariate analyses were used to identify clinicopathologic and imaging variables associated with progression-free survival (PFS) and overall survival (OS). Univariate analyses included the following variables: age, sex, pT and pN classifications, overall pTNM stage, histologic grade, resection margin, tumor lymphovascular invasion and perineural invasion, postoperative adjuvant therapy, gross total volume, SUVmax, MTV, and TLG. Results: The 3-y PFS and OS rates for all study patients were 66.9% and 81.6%, respectively. The median SUVmax, MTV, and TLG were 5.1 (range, 1.7&#8211;21.5), 16.2 mL (1.0&#8211;115.1 mL), and 24.4 g (2.1&#8211;224.4 g), respectively. Univariate analyses showed that there were significant correlations between pT classification, pN classification, MTV, and TLG and both PFS and OS (P < 0.05). However, SUVmax was not associated with either PFS (P = 0.111) or OS (P = 0.316). Multivariate analyses revealed that MTV (P = 0.011; hazard ratio, 11.50; 95% confidence interval, 1.45&#8211;91.01) and TLG (P = 0.038; hazard ratio, 3.55; 95% confidence interval, 1.07&#8211;11.76) were independent variables for PFS. Conclusion: Pretreatment values of MTV and TLG are independent prognostic factors in patients with intermediate or high-grade salivary gland carcinomas.
URI
http://pubs.kist.re.kr/handle/201004/46257
ISSN
01615505
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KIST Publication > Article
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