Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives

Title
Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives
Authors
심영선황현숙남길수최경일
Keywords
Thiourea; Parkinson's disease; Vinyl sulfoxide; Oxidative stress; Nrf2 activator
Issue Date
2013-08
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 34, NO 8, 2317-2320
Abstract
Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inflammatory activity. Both series of compounds showed moderate activity on HO-1 induction, and no inhibitory effect on NO production. Interestingly the thiourea compound 6d showed better HO-1 induction (71% SFN) than the corresponding isothiocyanate compound 6a (55% SFN). Overall, it seemed that more efficient electrophile is needed to get more effective Nrf2 activator.
URI
http://pubs.kist.re.kr/handle/201004/46260
ISSN
02532964
Appears in Collections:
KIST Publication > Article
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