Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus

Title
Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus
Authors
Jae Yeon KimHwanbum LeeKeun Sang OhSeho KweonOk-cheol JeonYoungro Byun김광명권익찬김상윤Soon Hong Yuk
Keywords
Core/shell nanoparticles; Layer-by-layer approach; Pluronics; Lipid bilayers; Sustained delivery of exenatide
Issue Date
2013-11
Publisher
Biomaterials
Citation
VOL 34, NO 33, 8444-8449
Abstract
A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDSePAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitroein vivo correlation was discussed in relation to manipulation of the NP structures.
URI
http://pubs.kist.re.kr/handle/201004/46272
ISSN
01429612
Appears in Collections:
KIST Publication > Article
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