Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus
- Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus
- Jae Yeon Kim; Hwanbum Lee; Keun Sang Oh; Seho Kweon; Ok-cheol Jeon; Youngro Byun; 김광명; 권익찬; 김상윤; Soon Hong Yuk
- Core/shell nanoparticles; Layer-by-layer approach; Pluronics; Lipid bilayers; Sustained delivery of exenatide
- Issue Date
- VOL 34, NO 33, 8444-8449
- A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDSePAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitroein vivo correlation was discussed in relation to manipulation of the NP structures.
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