Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedlander's Cyclization Reaction

Title
Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedlander's Cyclization Reaction
Authors
Mohammad Ashrafuddin Khan모하메드엘가말오창현
Keywords
Friedlander's reaction; Cyclization reaction; 2-Amino-4,5-dimethoxybenzaldehyde; Quinoline
Issue Date
2013-06
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 34, NO 6, 1848-1852
Abstract
6,7-Dimethoxy-2-methyl-3-(4-nitrophenoxy)quinoline was synthesized by Friedländer’s cyclization reaction. Different bases and solvents were tested in order to optimize the reaction conditions. The highest yields were obtained using piperidine in refluxing ethanol. Further reactions were carried out in order to prepare different diarylamide and diarylurea derivatives in moderate to high yields in order to examine their anticancer activities.
URI
http://pubs.kist.re.kr/handle/201004/46289
ISSN
02532964
Appears in Collections:
KIST Publication > Article
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