Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold

Title
Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold
Authors
김현진모하메드엘가말이용섭오창현
Keywords
2,3-Dihydropyrrolo[3,2-b]quinoline; Antiproliferative activity; Urea; Amide; Breast cancer
Issue Date
2013-08
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 34, NO 8, 2480-2486
Abstract
A new series of diarylamides and diarylureas having 2,3-dihydropyrrolo[3,2-b]quinoline scaffold was synthesized. Their in vitro antiproliferative activities were tested over NCI-60 cancer cell lines of nine different cancer types. Some target compounds showed good inhibition percentages over different cell lines. Among all the target compounds, compound 1f possessing 6,7-dimethoxy-2,3-dihydropyrrolo[3,2-b]quinoline nucleus, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed high selectivity against MCF7 and MDAMB- 468 breast cancer cell lines more than the other tested cell lines. Its inhibition percentages at 10 μM concentration over those two cell lines were 84.97% and 87.13%, respectively.
URI
http://pubs.kist.re.kr/handle/201004/46292
ISSN
02532964
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KIST Publication > Article
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