A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models

Title
A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models
Authors
장근혁황민태김수연장호성이관희
Keywords
zebrafish; toxicity; nanophosphor; quantum dot
Issue Date
2014-01
Publisher
Biomaterials
Citation
VOL 35, NO 1, 440-449
Abstract
Lanthanide ion-doped nanophosphors are an emerging group of nanomaterials with excellent optical properties, and have been suggested as alternatives to quantum dots. In this letter, we determine the invitro and in-vivo toxicity of b-NaYF4:Ce,Tb nanophosphors using Capan-1 cells and embryonic zebrafish, respectively. In particular, we are the first to report on the in-vivo toxicity of b-phase nanophosphors and examine phenotypic developmental abnormalities (growth retardation, heart deformity, and bent tail), apoptotic cell death, and changes in heart function due to the nanophosphors. This study suggests the use of b-NaYF4:Ce,Tb nanophosphors as alternatives for QDs in a wide variety of biomedical imaging applications.
URI
http://pubs.kist.re.kr/handle/201004/46321
ISSN
01429612
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KIST Publication > Article
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