Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
- Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
- 김경란; 김다래; 이태민; 이지영; 김병수; 권익찬; 안대로
- Issue Date
- Chemical communications
- VOL 49, NO 20, 2010-2012
- A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
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