Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells

Title
Drug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells
Authors
김경란김다래이태민이지영김병수권익찬안대로
Issue Date
2013-03
Publisher
Chemical communications
Citation
VOL 49, NO 20, 2010-2012
Abstract
A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.
URI
http://pubs.kist.re.kr/handle/201004/46345
ISSN
13597345
Appears in Collections:
KIST Publication > Article
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