Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging

Title
Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging
Authors
임창근아제이싱허정윤김대홍이경은전혜성고준석권익찬김세훈
Keywords
Flexible nanogels; Gadolinium coordination; Magnetic resonance/optical imaging; Metal-organic hybrids; Tumor targeting
Issue Date
2013-09
Publisher
Biomaterials
Citation
VOL 34, NO 28, 6846-6852
Abstract
Coordination polymer gels have been recognized as promising hybrid nanoplatforms for imaging and therapeutic applications. Here we report functional metal-organic coordinated nanogels (GdNGs) for in vivo tumor imaging, whose non-crystalline and elastic nature allows for long blood circulation, as opposed to the rapid systemic clearance of common nanohybrids with rigid/crystalline frameworks. The deformable structure of GdNGs was constructed by random crosslinking of highly flexible polyethyleneimines (PEI) with gadolinium (Gd3+) coordination. The in vitro characterization revealed that GdNGs have elasticity with an apparent Young’s modulus of 3.0 MPa as well as minimal cytotoxicity owing to the tight chelation of Gd3+ ions. In contrast to common T1-enhancing gadolinium complexes, GdNGs showed the capability of enhancing negative T2 contrast (r2 = 82.6 mM-1 s-1) due to the Gd3þconcentrated nanostructure. Systemic administration of fluorescently labeled GdNGs with core and overall hydrodynamic sizes of ~65 and ~160 nm manifested efficient targeting and dual-modality (magnetic resonance/fluorescence) imaging of tumor in a mouse model. The minimal filtration by the reticuloendothelial system (RES) suggests that the structural deformability helps the large colloids circulate in the blood stream for tumor accumulation. The unusual performance of a large Gd3+-complexed colloid (minimal RES sequestration and high T2 contrast enhancement) represents the versatile nature of nanoscopic organic-inorganic hybridization for biomedical applications.
URI
http://pubs.kist.re.kr/handle/201004/46346
ISSN
01429612
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