2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation

Title
2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation
Authors
이윤석김혜연윤혜미서재홍김영수신계정
Keywords
amyloid; Alzheimer; dementia; 알츠하이머병; 아밀로이드; 2-Phenylbenzofuran; Aβ aggregation inhibitor; Mitochondria; Alzheimer's disease
Issue Date
2013-11
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 23, NO 21, 5882-5886
Abstract
To obtain modulators for reducing mitochondrial damage by the inhibition of Aβ oligomer formation, 2-phenylbenzofuran derivatives were designed and prepared. Their inhibitory activity against Aβ fibril formation was screened using ThT fluorescence assay, and the effect of derivatives on mitochondrial function was evaluated using JC-1 and MTT assay. 2-Phenylbenzofuran derivatives with dimethylamino group at p-position had an excellent inhibitory activity against Aβ fibril formation. Particularly, compound 19m alleviated mitochondrial damage remarkably and possessed protective effects against Aβ-induced cytotoxicity.
URI
http://pubs.kist.re.kr/handle/201004/46354
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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