Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron

Title
Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron
Authors
김경란이용덕이태민김병수김세훈안대로
Keywords
Sentinel lymph node; DNA tetrahedron; In vivo imaging; Biocompatibility; Cancer
Issue Date
2013-07
Publisher
Biomaterials
Citation
VOL 34, NO 21, 5226-5235
Abstract
Sentinel lymph nodes (SLNs) are the first lymph nodes which cancer cells reach after traveling through lymphatic vessels from the primary tumor. Evaluating the nodal status is crucial in accurate staging of human cancers and accordingly determines prognosis and the most appropriate treatment. The commonly used methods for SLN identification in clinics are based on employment of a colloid of radionuclide or injection of a small dye. Although these methods have certainly contributed to improve surgical practice, new imaging materials are still required to overcome drawbacks of the techniques such as inconvenience of handling radioactive materials and short retention time of small dyes in SLNs. Here, we prepare a fluorescence-labeled DNA tetrahedron and perform SLN imaging by using the DNA nanoconstruct. With a successful identification of SLNs by the DNA nanoconstruct, we suggest that DNA tetrahedron hold great promises for clinical applications.
URI
http://pubs.kist.re.kr/handle/201004/46363
ISSN
01429612
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE