An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator

Title
An immunoassay utilizing the DNA-coated polydiacetylene micelles as a signal generator
Authors
Hoa Thi Hoang이태민김병수한기철안대로
Keywords
Polydiacetylene (PDA); Fluorescence intensity; Micelles; Alpha-fetoprotein (AFP); Immunoassay
Issue Date
2013-05
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 23, NO 9, 2675-2678
Abstract
Immunoassay is an important technique to detect the disease biomarkers and pathogenic biological agents which often present at low levels in clinical samples. To improve sensitivity of the immunoassay, here we described the DNA-coated, nano-sized micelles in which the DNA strands play a role as signal generators in an immunoassay. This micelle-based immunoassay was evaluated for quantitation of a liver cancer biomarker and the sensitivity of the method was compared with those of the conventional methods.
URI
http://pubs.kist.re.kr/handle/201004/46372
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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