An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery
- An injectable cell penetrable nano-polyplex hydrogel for localized siRNA delivery
- 김영민; 박미란; 송수창
- Cell penetration; gene delivery; nano-polyplex; polyplex hydrogel; Small interference RNA (siRNA)
- Issue Date
- VOL 34, NO 18, 4493-4500
- An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophos-phazene) and inducement of nano-polyplexes with siRNAs. After an injection of cell penetrable nano-polyplex solution into the body, it turns into a gel due to thermosensitivity of poly(organo- phosphazene). The gel maintains up to 4 weeks and the released 30 nm-sized nano-polyplexes from the gel induces highly effective siRNA delivery due to cell penetration. Accordingly, the new system shows a high gene silencing efficiency on only the target site in long-term with a single injection.
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