Injectable and biodegradable poly(organophosphazene) hydrogel as a delivery system of docetaxel for cancer treatment

Title
Injectable and biodegradable poly(organophosphazene) hydrogel as a delivery system of docetaxel for cancer treatment
Authors
조정교홍지민한태수양한광송수창
Keywords
biodegradable polymers; controlled drug delivery; docetaxel; gastric cancer; hydrogels; injectable; poly(organophosphazene); sustained-release system; thermosensitive
Issue Date
2013-07
Publisher
Journal of drug targeting
Citation
VOL 21, NO 6, 564-573
Abstract
Although docetaxel (DTX) is an advanced taxoid, further augmentation of its properties is still required, such as improvement in its low aqueous solubility. Herein, we report the development of biodegradable/injectable poly(organophosphazene) (PPZ) hydrogels for the delivery of DTX without the use of organic solvents. An aqueous solution of PPZ containing a-amino-o-methoxy-poly(ethylene glycol) (AMPEG) 750 instead of AMPEG 550 was prepared, thereby increasing the erosion capacity of the hydrogel by judicious balance of the hydrophobic/hydrophilic moieties. The safety of the hydrogel was demonstrated using a biocompatibility test. The PPZ aqueous solution (8 wt%) containing DTX exhibited a thermosensitive sol–gel–sol transition that was independent of the concentration of DTX (1–3 mg/mL). The in vitro release study indicated that the dominant release mechanism was either erosion or diffusion/erosion-controlled release depending on the DTX content of the hydrogel. The in vivo anticancer effect of the intratumorally injected PPZ system in human gastric cancer cell-xenografted mice was evaluated, which demonstrated a significantly (p50.01) enhanced effect of the DTX-PPZ hydrogel system compared to the control (DTX solution, i.v.). In conclusion, the PPZ hydrogel may be a promising candidate for DTX delivery, affecting a decrease in the size of tumors with little toxicity prior to exeresis.
URI
http://pubs.kist.re.kr/handle/201004/46376
ISSN
1061186X
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KIST Publication > Article
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