"pH phoresis": A New Concept That Can Be Used for Improving Drug Delivery to Tumor Cells

Title
"pH phoresis": A New Concept That Can Be Used for Improving Drug Delivery to Tumor Cells
Authors
원유연Hoyoung Lee
Keywords
Drug delivery; Tumor; Cancer; pH; Nanoparticle; Polyamine
Issue Date
2013-09
Publisher
Journal of controlled release
Citation
VOL 170, NO 3, 396-400
Abstract
We propose a new concept describing how nanoparticles composed of weak polybases (such as polyamines) would behave when they are exposed to a pH gradient; weak polybase-containing particles will tend to accumulate preferentially in low pH regions under a pH gradient environment. This phenomenon, which we term “pH phoresis”, may provide a useful mechanism for improving the delivery of drugs to cancer cells in solid tumor tissues.
URI
http://pubs.kist.re.kr/handle/201004/46435
ISSN
01683659
Appears in Collections:
KIST Publication > Article
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