FLEXIBLE NEURAL PROBE EMBEDDED MICROCHANNEL AND FIBER GUIDE FOR MULTIFLE STIMULATION
- FLEXIBLE NEURAL PROBE EMBEDDED MICROCHANNEL AND FIBER GUIDE FOR MULTIFLE STIMULATION
- 이부용; 진주영; 박정호; 김진석
- Optogenetics; MEMS; Neural probe; Flexible material
- Issue Date
- Transducers 2013
- There have been numerous efforts to understand nervous systems and develop treatments for its disorders. Patch clamp has been explored as an effective tool to record intracellular neural signals with high signal-to-noise ratio but the simultaneous access of multiple neurons is limited due to manual operation of single electrode. Various MEMS neural probes have been introduced to simultaneously record as well as stimulate multiple-sites for studying central nervous system at the cellular level.
Although massive-parallel access of single neuron activities has been realized in three-dimensional probe shanks for both recording and stimulation, the area of monitoring neural activities are still more than 100μm around each site and specific target neurons cannot be selectively screened. Electrical stimulation injects a large amount of current into the tissue to stimulate neurons in the vicinity of stimulating sites. This electrical stimulation may damage the neurons and also suffers from poor spatial resolution limited by the propagation of electrical pulse through the solution and thus all the neurons within the vicinity of the stimulation electrode are potentially excited. Also, the rigidity of established silicon devices induces tissue damage during the insertion and the experiment of the device.
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