Identification of genetic/epigenetic biomarkers for supporting decision of VOCs exposure

Title
Identification of genetic/epigenetic biomarkers for supporting decision of VOCs exposure
Authors
안유리김승준유소연윤효정송미경류재천황승용
Keywords
Volatile organic compounds; Biomarker; Epigenetic; MicroRNA; Methylation
Issue Date
2013-03
Publisher
BioChip Journal
Citation
VOL 7, NO 1, 1-5
Abstract
Ethylbenzene, toluene and xylene are widely used volatile organic compounds (VOCs). VOCs are dangerous to human health or cause harm to the environment. The assessment of VOC exposure maybe carried out through a number of techniques. One of them, the epigenetic biomarker applies a new technology. Environmental epigenetics focuses on how cells or organisms respond to environmental factors to create altered phenotypes or diseases. In this study, our intention was to conduct an investigation of epigenetic biomarkers in VOCs. For the experiment, we used the DNAs and RNAs from VOC exposed human blood and VOCs treated cell lines. Then, we compared the data using microarray fold change, real-time PCR and methylation specific PCR. As a result, we identified five microRNAs (miR-520g, miR-424, miR-210, miR-21, and miR-142-3p), three methylation regions (SERPINB5, ZC3H3, and PCSK6) and four transcripts (CRCT1, RUNX3, PCDH11X, and PCSK6), which could be used as biomarkers for VOCs, becommings the foundation for a system which can predict VOC exposure.
URI
http://pubs.kist.re.kr/handle/201004/46478
ISSN
19760280
Appears in Collections:
KIST Publication > Article
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