Microfluidization Enhances Absorption of Lutein from Chlorella vulgaris by Caco-2 Intestinal Cells and Adult Rats
- Microfluidization Enhances Absorption of Lutein from Chlorella vulgaris by Caco-2 Intestinal Cells and Adult Rats
- 차광현; 정상훈; 안홍열; 강석우; 김경아; 판철호
- chlorella; microfluidization; lutein; bioavailability; in vivo rat model
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- The bioavailability of lutein from intact and microfluidized Chlorella vulgaris was evaluated using a rat model and a coupled simulated digestion/Caco-2 cell transport assay. C. vulgaris was microfluidized at various pressures (0–20,000 psi); particle size decreased as the microfluidization pressure increased. The number of aqueous lutein micelles was 3-fold higher in C. vulgaris microfluidized at 20,000 psi (MC20K) than in untreated C. vulgaris (UC). The amount of lutein transported by Caco-2 cells was higher following incubation with MC20K than following incubation with UC. The concentrations of lutein in plasma, liver, and eyes of rats were significantly higher following administration of MC20K than following administration of UC. The amount of lutein rats absorbed correlated with the amount of microfluidized C. vulgaris they received. These results show that microfluidization ameliorates the release of lutein from C. vulgaris and might increase the bioavailability of lutein from lutein-rich microalgae.
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