Microfluidization Enhances Absorption of Lutein from Chlorella vulgaris by Caco-2 Intestinal Cells and Adult Rats

Title
Microfluidization Enhances Absorption of Lutein from Chlorella vulgaris by Caco-2 Intestinal Cells and Adult Rats
Authors
차광현정상훈안홍열강석우김경아판철호
Keywords
chlorella; microfluidization; lutein; bioavailability; in vivo rat model
Issue Date
2013-08
Publisher
한국식품과학회
Abstract
The bioavailability of lutein from intact and microfluidized Chlorella vulgaris was evaluated using a rat model and a coupled simulated digestion/Caco-2 cell transport assay. C. vulgaris was microfluidized at various pressures (0–20,000 psi); particle size decreased as the microfluidization pressure increased. The number of aqueous lutein micelles was 3-fold higher in C. vulgaris microfluidized at 20,000 psi (MC20K) than in untreated C. vulgaris (UC). The amount of lutein transported by Caco-2 cells was higher following incubation with MC20K than following incubation with UC. The concentrations of lutein in plasma, liver, and eyes of rats were significantly higher following administration of MC20K than following administration of UC. The amount of lutein rats absorbed correlated with the amount of microfluidized C. vulgaris they received. These results show that microfluidization ameliorates the release of lutein from C. vulgaris and might increase the bioavailability of lutein from lutein-rich microalgae.
URI
http://pubs.kist.re.kr/handle/201004/46536
Appears in Collections:
KIST Publication > Conference Paper
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