Pleurospermum camtschaticum Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance
- Pleurospermum camtschaticum Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance
- 김명석; 임수지; 노주원
- Pleurospermum camtschaticum; lipogenesis; HepG2; triglyceride; AMPK
- Issue Date
- , 135-135
- Pleurospermumcamtschaticumhas been considered to possess different benefits such as antioxidant, antiinflammation, anticancer, and antihyperlipidemia. The present study was aimed to investigate the protective effects of Pleurospermumcamtschaticumextract(PCE) on hepatocyte cultured with high fatty acid and the underlying mechanisms. By using human hepatoma cell HepG2 as cell model, the results showed that PCE suppressed fatty acid synthesis and enhanced fatty acid oxidation, contributing to amelioration of lipid accumulation induced by oleic acid. Moreover, PCE also inhibited acetyl coenzyme A carboxylase activities by stimulating adenosine monophosphate-activated protein kinase. PCE attenuated the expression of sterol regulatory element-binding protein-1 and its target molecules, such as fatty acid synthase. In contrast, the lipolytic enzyme expressions of peroxisome proliferator activated receptor α and carnitinepalmitol- transferase-1 were increased. This study suggests the hypolipidemic effects of PCE occur via phosphorylation of AMPK and inhibition of lipid biosynthesis and stimulation of lipolysis. Therefore, the PCE may actively prevent nonalcoholic fatty liver disease.
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