Inhibitory Effect of Hovenia dulcis on IgE-Mediated Mast Cell Activation
- Inhibitory Effect of Hovenia dulcis on IgE-Mediated Mast Cell Activation
- 김명석; 임수지; 노주원
- Hovenia dulcis; IgE; histamine; degranulation
- Issue Date
- , 135-135
- Immediate-type hypersensitivity is characterized by elevated levels of immunoglobulin E(IgE) and activated mast cell plays a crucial role by releasing granule contents, lipid-derived mediators,cytokines, and chemokines. To evaluate the antiallergic effects of Hoveniadulcis extract (HDE), we determined its effects ondegranulation, and inflammatory mediators in IgE-stimulated rat basophilic leukemia cells. HDE inhibited secretion of β-hexosaminidase and histamine. HDE reduced the production of prostaglandin E2 and the mRNA expression of cyclooxygenase-2, interleukin (IL)-4, IL-13, and tumor necrosis factor-α. Furthermore, HDEattenuated phosphorylation of the mitogen-activated protein kinases (MAPK) extracellularsignal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) expression. These resultsindicate that HDEmight be useful as an agent against immediate-type hypersensitivity.
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