Stability and bioaccessibility of ginsenosides from white and red ginseng in the simulated digestion

Title
Stability and bioaccessibility of ginsenosides from white and red ginseng in the simulated digestion
Authors
김은옥차광현이은하판철호엄병헌
Keywords
bioavailability; digestive stability; ginsenosides; simulated digestion; white ginseng; red ginseng
Issue Date
2013-08
Publisher
한국식품과학회
Abstract
This study investigated stability and bioaccessibility of ginsenosides during simulated digestion of white (WG) and red ginseng (RG) powder. Most ginsenosides present in WG and RG were relatively stable during oral, gastric, and small intestinal digestion using a static model system. However, RG had a higher content (1148.7 mg/100 g dry weight) of total ginsenosides compared to WG (664.2 mg/100 g). The protopanaxadiol (PPD)/protopanaxatriol (PPT) ratio of RG was approximately 3.6-fold greater than for WG. Bioaccessibility of total ginsenosides in aqueous fraction during simulated digestion of WG and RG was gradually increased 74.8%-86.4% and 55.2-84.3%, respectively, and PPD/PPT ratio ratio of RG was 4.6-fold greater than for WG. Ginsenoside through Caco-2 cell monolayers had low permeability (< 10×10-6 cm/s). The permeability in basolateral (BL) to apical (AP) direction was 10-fold greater than that in AP to BL direction. These findings suggest that ginsenoside compo-sitions of WG and RG affect the bioaccessibility of ginsenosides during digestion and that transport of ginsenosides through Caco-2 cells is poor despite moderate apparent bioaccessibility.
URI
http://pubs.kist.re.kr/handle/201004/46562
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KIST Publication > Conference Paper
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