Stability and bioaccessibility of ginsenosides from white and red ginseng in the simulated digestion
- Stability and bioaccessibility of ginsenosides from white and red ginseng in the simulated digestion
- 김은옥; 차광현; 이은하; 판철호; 엄병헌
- bioavailability; digestive stability; ginsenosides; simulated digestion; white ginseng; red ginseng
- Issue Date
- This study investigated stability and bioaccessibility of ginsenosides during simulated digestion of white (WG) and red ginseng (RG) powder. Most ginsenosides present in WG and RG were relatively stable during oral, gastric, and small intestinal digestion using a static model system. However, RG had a higher content (1148.7 mg/100 g dry weight) of total ginsenosides compared to WG (664.2 mg/100 g). The protopanaxadiol (PPD)/protopanaxatriol (PPT) ratio of RG was approximately 3.6-fold greater than for WG. Bioaccessibility of total ginsenosides in aqueous fraction during simulated digestion of WG and RG was gradually increased 74.8%-86.4% and 55.2-84.3%, respectively, and PPD/PPT ratio ratio of RG was 4.6-fold greater than for WG. Ginsenoside through Caco-2 cell monolayers had low permeability (< 10×10-6 cm/s). The permeability in basolateral (BL) to apical (AP) direction was 10-fold greater than that in AP to BL direction. These findings suggest that ginsenoside compo-sitions of WG and RG affect the bioaccessibility of ginsenosides during digestion and that transport of ginsenosides through Caco-2 cells is poor despite moderate apparent bioaccessibility.
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