Anti-diabetic effect of amorphastilbol through PPARα/γ dual activation in db/db mice

Title
Anti-diabetic effect of amorphastilbol through PPARα/γ dual activation in db/db mice
Authors
이우정함정엽권학철김용기김수남
Keywords
Amorphastilbol; Anti-diabetic; PPARα/γ agonist
Issue Date
2013-03
Publisher
Biochemical and biophysical research communications
Citation
VOL 432, NO 1, 73-79
Abstract
Peroxisome proliferator-activated receptors (PPARs) have been considered as desirable targets for metabolic syndrome treatments, even though their specific agonists have several side effects, including body weight gain, edema, and tissue failure. The effects of amorphastilbol (APH) on glucose- and lipid metabolism were investigated with in vitro 3T3-L1 adipocyte systems and in vivo db/db mice model. APH selectively stimulates the transcriptional activities of both PPARα and PPARγ, which are able to enhance fatty acid oxidation and glucose utilization. Furthermore, APH improves glucose and lipid impairment in db/db mice. More importantly, there are no significant side effects, such as weight gain or hepatomegaly, in APH-treated animals, implying that APH do not adversely affect liver or lipid metabolism. All our data suggest that APH can be used as potential therapeutic agents against type 2 diabetes and related metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.
URI
http://pubs.kist.re.kr/handle/201004/46584
ISSN
0006291X
Appears in Collections:
KIST Publication > Article
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