Protective Effects of Esculin on Streptozotocin-induced liver injury in diabetic mice
- Protective Effects of Esculin on Streptozotocin-induced liver injury in diabetic mice
- 이우정; 강기성; 정유정; 전영식; 함정엽; 김형자; 김수남
- Esculin; Diabetes; mellitus; Oxidative stress; Liver
- Issue Date
- , 133-133
- Diabetes mellitus is one of the most common endocrine metabolic disorders. Oxidative stress plays a major role in the pathogenesis of diabetes mellitus. Streptozotocin (STZ)-induced oxidative stress is implicated in both liver injuries as well in β - cell destruction.
Diabetes was induced by streptozotocin (STZ) injection (ip) at a dose of 200 mg/kg. STZ-induced diabetic mice were orally administered with ES (20mg/kg) for 2 weeks.
In ES administrated STZ-induced diabetic model, water intake was decreased than STZ-injected control mice. In addition, blood glucose, fasting blood glucose, and total cholesterol were decreased. Liver weight was not significantly reduced compared with STZ-injected contrel mice. Additionally, COX-2 protein expression and G6Pase mRNA expression in liver tissue were reduced compared with STZ-injected control mice.
We suggested that ES might be considered as an antioxidant in preventing the development of hyperglycemia, and as a treatment for STZ-induced diabetic liver in mice.
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