Abietic acid inhibit ultraviolet B(UVB)-induced matrix metalloproteinases(MMP)-1 expression in human dermal fibroblast through peroxisome proliferator-activated receptor(PPAR) a/r dual activation

Title
Abietic acid inhibit ultraviolet B(UVB)-induced matrix metalloproteinases(MMP)-1 expression in human dermal fibroblast through peroxisome proliferator-activated receptor(PPAR) a/r dual activation
Authors
전영식이우정정유정강기성함정엽김용기김수남
Issue Date
2013-05
Publisher
생화학분자생물학회 (KSBMB)
Abstract
UVB irradiation is an important environmental factor that can lead to that wrinkle is caused of skin extracellular matrix denaturation, skin cancer and skin inflammation. PPARs which are members of the nuclear receptor superfamily, are receptor of steroid-activated transcription factors that consist of three-form(PPARα,β/δ,γ). They are known as transcriptional regulators of lipid metabolism and glucose homeostasis. However, PPARα and PPARγ in recent studies have revealed their receptor importance in age-related inflammation and photo-aging as regulators of AP-1 and NF-κB, cytokine, MMPs. In this study, we confirm that ability of Abietic acid, natural product, has PPARα/γ dual activator and anti-inflammation role of PPARα/γ in Hs68 human fibroblast cell. UVB irradiation induces overexpression of COX-2, iNOS, MMP-1, MMP-2 and inflammatory cytokine and also activates phosphorylation of the c-fos, c-jun subunit of AP-1, the nuclear translocation of the p65 subunit of NF-κB. Abietic acid, PPARα/γ dual activator, has ameliorated UVB irradiation induced expression of cytokine, COX-2, MMP-1, 2 and inhibited AP-1, NF-κB activation in a dose dependent manner. Taken together, our data suggest that Abietic acid, PPARα/γ activation and protects UVB radiation induced photo-aging.
URI
http://pubs.kist.re.kr/handle/201004/46589
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KIST Publication > Conference Paper
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