Abietic acid inhibit ultraviolet B(UVB)-induced matrix metalloproteinases(MMP)-1 expression in human dermal fibroblast through peroxisome proliferator-activated receptor(PPAR) a/r dual activation
- Abietic acid inhibit ultraviolet B(UVB)-induced matrix metalloproteinases(MMP)-1 expression in human dermal fibroblast through peroxisome proliferator-activated receptor(PPAR) a/r dual activation
- 전영식; 이우정; 정유정; 강기성; 함정엽; 김용기; 김수남
- Issue Date
- 생화학분자생물학회 (KSBMB)
- UVB irradiation is an important environmental factor that can lead to that wrinkle is caused of skin extracellular matrix denaturation, skin cancer and skin inflammation.
PPARs which are members of the nuclear receptor superfamily, are receptor of steroid-activated transcription factors that consist of three-form(PPARα,β/δ,γ). They are known as transcriptional regulators of lipid metabolism and glucose homeostasis. However, PPARα and PPARγ in recent studies have revealed their receptor importance in age-related inflammation and photo-aging as regulators of AP-1 and NF-κB, cytokine, MMPs.
In this study, we confirm that ability of Abietic acid, natural product, has PPARα/γ dual activator and anti-inflammation role of PPARα/γ in Hs68 human fibroblast cell. UVB irradiation induces overexpression of COX-2, iNOS, MMP-1, MMP-2 and inflammatory cytokine and also activates phosphorylation of the c-fos, c-jun subunit of AP-1, the nuclear translocation of the p65 subunit of NF-κB.
Abietic acid, PPARα/γ dual activator, has ameliorated UVB irradiation induced expression of cytokine, COX-2, MMP-1, 2 and inhibited AP-1, NF-κB activation in a dose dependent manner. Taken together, our data suggest that Abietic acid, PPARα/γ activation and protects UVB radiation induced photo-aging.
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