Gomisin J and Angeloylgomisin H Isolated from Schisandra chinensis Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance

Title
Gomisin J and Angeloylgomisin H Isolated from Schisandra chinensis Inhibit Oleic Acid Induced Lipid Accumulation by Reduction of Lipogenesis and Promotion of Hepatic Lipid Clearance
Authors
김명석임수지노주원
Keywords
Schisandra chinensis; Gomisin J; Angeloylgomisin H; HepG2; Lipogenesis
Issue Date
2013-11
Publisher
한국식품영양과학회지
Abstract
Dibenzocyclooctadiene lignans isolated from the fruit of S. chinensis have been reported to possess anti-inflammatory, antioxidant, antiproliferative, and proapoptotic activities. The present study was aimed to investigate the protective effects of gomisin J and angeloylgomisin H isolated from Schisandra chinensis on hepatocyte cultured with high fatty acid and the underlying mechanisms. By using human hepatoma cell HepG2 as cell model, the results showed that gomisin J and angeloylgomisin H suppressed fatty acid synthesis and enhanced fatty acid oxidation, contributing to amelioration of lipid accumulation induced by oleic acid. Moreover, gomisin J and angeloylgomisin H also inhibited acetyl coenzyme A carboxylase activities by stimulating adenosine monophosphate-activated protein kinase. gomisin J and angeloylgomisin H attenuated the expression of sterol regulatory element-binding protein-1 and its target molecules, such as fatty acid synthase. In contrast, the lipolytic enzyme expressions of peroxisome proliferator activated receptor α and carnitinepalmitol- transferase-1 were increased. This study suggests the hypolipidemic effects of gomisin J and angeloylgomisin H occur via phosphorylation of AMPK and inhibition of lipid biosynthesis and stimulation of lipolysis. Therefore, the gomisin J and angeloylgomisin H may actively prevent nonalcoholic fatty liver disease.
URI
http://pubs.kist.re.kr/handle/201004/46622
ISSN
12263311
Appears in Collections:
KIST Publication > Conference Paper
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