Inhibitory effect of Thuja orientalis on aldo-keto reductase family 1 B10

Title
Inhibitory effect of Thuja orientalis on aldo-keto reductase family 1 B10
Authors
이주영정우석송대근이은하정상훈이재권판철호
Keywords
AKR1B10; aldo-keto reductase; amentoflavone; anticancer; Thuja orientalis
Issue Date
2013-11
Publisher
과학교육연구논총
Citation
VOL 29, NO 1, 25-33
Abstract
This study is to evaluate the inhibitory effect of Thuja orientalis leaves on aldo-keto reductase family 1 B10 (AKR1B10), a potential cancer therapeutic target. To identify the active compounds, seven compounds from the ethyl acetate fraction of T. orientalis were tested for their inhibitory effects on recombinant human AKR1B10 (rhAKR1B10). Among them, amentoflavone was the best inhibitor of rhAKR1B10. The inhibitory rate of amentoflavone against rhAKR1B10 was 81% at 1μM with an IC50 value of 0.86μM, and enzyme kinetic study revealed its inhibition mode to be mixed-competitive.
URI
http://pubs.kist.re.kr/handle/201004/46633
ISSN
1229229X
Appears in Collections:
KIST Publication > Article
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