Abnormal maternal behavior in mice lacking phospholipase Cβ1

Title
Abnormal maternal behavior in mice lacking phospholipase Cβ1
Authors
김혜진고혜영
Keywords
maternal; phospholipase C beta 1; mice; motivation
Issue Date
2013-11
Publisher
SOCIETY FOR NEUROSCIENCE
Abstract
Hormones, neuropeptides, and neurotransmitters involved in parental behavior act via G-protein-coupled receptors (GPCR), many of which in turn activate plasma membrane enzymes including phospholipase C (PLC) β isoforms. In the present study, we found that PLCβ1-knockout (KO) dams display abnormal pattern of maternal behavior. During -24 hr ~ +12 hr (24 hr before ~ 12 hr after parturition), KO dams performed normal maternal behaviors such as, nesting, licking, grooming, hovering and pup retrieving. From ~+18 hr, however, KO dams no longer took care of their pups, and eventually all pups died in a few days. KO dams display normal behavior at the preparation & onset phases, but fail to proceed to maintenance phase. In maternal behavior, the system goes through a variety of complex changes in brain physiology from the preparation, onset, to maintenance phase, the mechanism of which is yet poorly understood. The present observation suggests that PLCβ1 may play a key role in the transition from the onset to the maintenance phase of maternal behavior (12~18hr post partum), and therefore PLCβ1-KO mice can be a good rodent model for studying biological basis of the maintenance of maternal behavior. As a preliminary attempt to address the question of neural substrate of the transition to the maintenance phase, we compared neuronal activation patterns in KO and wild-type dams’ brains using FosB immunohistochemistry.
URI
http://pubs.kist.re.kr/handle/201004/46668
Appears in Collections:
KIST Publication > Conference Paper
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