Paternal attentiveness can be affected by behavioral phenotype of dam

Paternal attentiveness can be affected by behavioral phenotype of dam
paternal; phospholipase C beta 1; mice
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The question about the emergence of affiliative social behavior in mammals can be addressed by studying male paternal brain. Paternal care behavior has been studied mainly in monogamous & biparental rodents such as prairie voles, California mice, and marmosets in the wild, where the sires are spontaneously paternal. Other rodents (laboratory mice, rats) show paternal behaviors that are induced and/or encouraged by various environmental/social factors (sensory inputs from dams and/or pups, separation from pups), whose putative neural systems are different from those of biparental species. In the present study, we have observed that wild-type (WT) B6/129 sires become significantly more paternally attentive when they are paired with PLCβ1-KO dams, which neglect pups from ~+18hr post partum (pp) on (see adjacent poster by Kim & Koh), and that the company of this paternally more attentive sire fundamentally affects actual pup survival rate. This result suggests that the paternal attentiveness may be modulated dynamically by environmental factors (here, genotype, therefore maternal behavioral phenotype of the dam, and/or the resultant condition of pups) in this strain, and that this kind of modulation may have evolutionarily adaptive value. Therefore, this mating system model may provide opportunities to study the adaptive significance and the neural mechanism of modulation of paternal attentiveness in non-biparental species. As a preliminary attempt to find the neural mechanism of the change in paternal attentiveness, we compared neuronal activation patterns in the brains of WT sires mated with PLCβ1-KO and those mated with WT dams using FosB immunohistochemistry.
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