Protective effects of chlorogenic acid metabolites and coffee extract on oxidative and endoplasmic reticulumstress-induced retinal degeneration
- Protective effects of chlorogenic acid metabolites and coffee extract on oxidative and endoplasmic reticulumstress-induced retinal degeneration
- 장호림; 김경아; 조형; 안홍열; 이은하; 정상훈; 이창용
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- Coffee is one of the most popular and consumed beverages in the world and is associated with a series of benefits for human health. Chlorogenic acids, the most abundant secondary metabolites in coffee during the coffee brewing process, have several pharmacological activities including antioxidant, hepato-protectant, antibacterial, antihistaminic, and anticancer, among others. However, there is lack of studies for neuroprotective effect of chlorogenic acids and its metabolites especially in the retina.
Chlorogenic acids and coffee extracts reduce retinal degeneration from oxidative and ER stress in vitro and in vivo. Also, metabolites of chlorogenic acids, 3,4-dihydroxyphenylacetic acid and 3-(4-hydroxyphenyl) propionic acid, might be a potential therapeutic agent for retinal degeneration.
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