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dc.contributor.author구밍야오-
dc.contributor.author권학철-
dc.contributor.author송민옥-
dc.contributor.author고현석-
dc.contributor.author차진욱-
dc.contributor.author이원종-
dc.contributor.author양현옥-
dc.date.accessioned2015-12-03T01:06:01Z-
dc.date.available2015-12-03T01:06:01Z-
dc.date.issued201306-
dc.identifier.citationVOL 19, NO 3, 242-250-
dc.identifier.issn12263907-
dc.identifier.other41068-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/46703-
dc.description.abstractThe autophagy-lysosomal pathway is an important protein degradation system, and its dysfunction has been implicated in a number of neurodegenerative diseases, including Parkinson's disease. Raphani Semen, one of the herbs of Yeoldahanso-tang (YH), has neuroprotective effects via the autophagy pathway. The activity-guided method was used to isolate and identify the components of Raphani Semen. In this experiment, the total extract of Raphani Semen was partitioned to n-butanol, methylene chloride, and water fractions. Flow cytometry data showed that only the water fraction showed autophagy-inducing activity in vitro. Compounds 1 and 2 were isolated from this water fraction by preparative HPLC separation. The structures of compounds 1 and 2 were identified as stachyose and raffinose, respectively, by the analysis of various spectral data ( NMR, NMR, and MS) and comparisons with standard stachyose and raffinose. Of these two compounds, raffinose showed autophagy-inducing activity in PC12 cells through the mTOR pathway.-
dc.publisherNatural Product Sciences-
dc.subjectAutophagy-
dc.subjectRaffinose-
dc.subjectRaphani semen-
dc.subjectRaphanus sativa L.-
dc.subjectCruciferae-
dc.titleIsolation and Identification of an Autophay-inducing Compound from Raphani Semen-
dc.typeArticle-
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