Inhibitory Effect of Endarachne binghamiae Extract on Melanin Synthesis
- Inhibitory Effect of Endarachne binghamiae Extract on Melanin Synthesis
- 전영식; 정유정; 염종경; 김용기; 김수남
- Endarachne binghamiae; Melanin; Tyrosinase; α-glucosidase; Glycosylation
- Issue Date
- 한국자원식물학회지 (Korean Journal of Plant Resources)
- VOL 26, NO 5, 526-532
- In this study, we investigated the effect of 88 marine algae extracts on melanin synthesis to develop new whitening agents. Among varieties of marine algae tested, the ethyl acetate extracts from Endarachne binghamiae (EB), Scytosiphon lomentaria, Sargassum yezoense, Ecklonia cava and Sargassum fusiforme inhibited melanin synthesis in melan-a cells. EB treatment showed the strongest inhibitory activity in melanin synthesis, compared with that of other extracts. EB-mediated inhibition of melanin synthesis appeared to be associated with inhibition of α-glucosidase-dependent glycosylation of tyrosinase in melan-a cells. In addition, EB treatment did not affect mushroom tyrosinase or cell-extracted tyrosinase activity in vitro. Taken together, our findings suggest that anti-browning effect of EB on skin is mediated through regulation of α-glucosidase activity and subsequent inhibition of tyrosinase activity and melanin synthesis, and further development of EB as a potential agent for skin whitening.
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