Liver-Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination

Title
Liver-Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination
Authors
민현수손세진이태웅구희범윤홍열나진희최용석박재형이재용한문희박랑운김인산정서영이계한김선화권익찬김광명
Keywords
ultrasound imaging; ultrasound contrast agents; hyaluronic acid (HA); perfluoropentane (PFP); liver-targeting treatments
Issue Date
2013-11
Publisher
Advanced functional materials
Citation
VOL 23, NO 44, 5518-5529
Abstract
With the increasing demand for instant real-time ultrasound (US) imaging of a specific organ, target-specific and long-circulating ultrasound contrast agents are of special interest. A new species of echogenic hyaluronic acid nanoparticles is presented as an ultralong-acting, liver-specific, US contrast agent that is distinct from conventional gas-filled microbubbles. Using an oil-in-water (O/W) emulsification method, bioinert and hydrophobic perfluoropentane (PFP) is encapsulated as an ultrasound gas precursor into hyaluronic acid nanoparticles (HANPs) using hydrophobic interactions. HANPs are formulated by self-assembly, with amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugating in aqueous conditions. The resulting echogenic PFP-encapsulated HANPs (Echo-NPs) show solid nanostructures, differentiated from core-empty conventional microbubbles, and exhibiting outstanding physical properties as an ultrasound contrast agent. They are more stable and robust echogenic solid bodies with an in vivo favorable hydrodynamic size and because PFPs vaporize gradually, their expansion process is very slow in body conditions. After several systemic circulations, echo-NPs generated intense and ultralong echo signals for US imaging at the target site. The echogenic properties of Echo-NPs show a significantly increased half-life and echo persistence, compared with conventional microbubbles. The results clearly show that echo-NPs outperform conventional microbubbles in terms of both physical and echogenic in vitro and in vivo properties.
URI
http://pubs.kist.re.kr/handle/201004/46879
ISSN
1616301X
Appears in Collections:
KIST Publication > Article
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