Mechanisms producing time course of cerebellar long-term depression

Title
Mechanisms producing time course of cerebellar long-term depression
Authors
김태곤게이코 야마모토
Keywords
Long-term depression; Maintenance phase; Stochastic nature; Threshold behavior
Issue Date
2013-11
Publisher
Neural Networks
Citation
VOL 47, 32-35
Abstract
Cerebellar long-term depression (LTD) is induced by short-lasting synaptic activities, progressively expressed, and then maintained for hours or longer. Short-lasting events, such as calcium transients, are activated and required for the induction of LTD. Further, a positive-feedback kinase loop was shown to follow the transient events and to aid the transition between LTD induction and prolonged synaptic depression. Yet, it is not entirely clear as to how LTD is maintained and how the maintenance mechanisms are activated, mainly because of a lack of experimental studies regarding this topic, while an idea has been theoretically proposed. A new analysis of the experimental results suggests that early maintenance mechanisms display a threshold behavior and that they may be of stochastic nature. This suggestion is conceptually consistent with an idea from a computational study, which postulates that other bistable switch systems are required for LTD maintenance. We thus propose that cellular mechanisms showing a threshold behavior and a stochastic nature maintain LTD, and that future experimental studies in search of such mechanisms would be an important step toward fully understanding the time course of LTD.
URI
http://pubs.kist.re.kr/handle/201004/46891
ISSN
08936080
Appears in Collections:
KIST Publication > Article
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