GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal

Title
GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal
Authors
Sukwon LeeBeomjong Song김정연Kyungjoon ParkIngie HongBobae An송상호Jiwon LeeSungmo ParkJihye KimDongeun Park이창준Kyungjin KimKi Soon ShinRichard W TsienSukwoo Choi
Issue Date
2013-10
Publisher
Nature neuroscience
Citation
VOL 16, NO 10, 1436-1444
Abstract
Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasticity, enhanced excitatory synaptic strength, activity of synaptic GluA2-lacking AMPA receptors and Ser831 phosphorylation of synaptic surface GluA1 in the lateral nucleus of the amygdala (LAn) of fear-extinguished rats. Consistently, the induction threshold for LAn synaptic potentiation was considerably lowered after extinction, and renewal occluded this low-threshold potentiation. The low-threshold potentiation (a potential cellular substrate for renewal), but not long-term potentiation, was attenuated by dialysis into LAn neurons of a GluA1-derived peptide that competes with Ser831-phosphorylated GluA1. Microinjections of the same peptide into the LAn attenuated fear renewal, but not fear learning. Our findings suggest that GluA1 phosphorylation constitutes a promising target for clinical treatment of aberrant fear-related disorders.
URI
http://pubs.kist.re.kr/handle/201004/46904
ISSN
10976256
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KIST Publication > Article
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