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dc.contributor.authorSukwon Lee-
dc.contributor.authorBeomjong Song-
dc.contributor.author김정연-
dc.contributor.authorKyungjoon Park-
dc.contributor.authorIngie Hong-
dc.contributor.authorBobae An-
dc.contributor.author송상호-
dc.contributor.authorJiwon Lee-
dc.contributor.authorSungmo Park-
dc.contributor.authorJihye Kim-
dc.contributor.authorDongeun Park-
dc.contributor.author이창준-
dc.contributor.authorKyungjin Kim-
dc.contributor.authorKi Soon Shin-
dc.contributor.authorRichard W Tsien-
dc.contributor.authorSukwoo Choi-
dc.date.accessioned2015-12-03T01:07:39Z-
dc.date.available2015-12-03T01:07:39Z-
dc.date.issued201310-
dc.identifier.citationVOL 16, NO 10, 1436-1444-
dc.identifier.issn10976256-
dc.identifier.other41278-
dc.identifier.urihttp://pubs.kist.re.kr/handle/201004/46904-
dc.description.abstractFear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasticity, enhanced excitatory synaptic strength, activity of synaptic GluA2-lacking AMPA receptors and Ser831 phosphorylation of synaptic surface GluA1 in the lateral nucleus of the amygdala (LAn) of fear-extinguished rats. Consistently, the induction threshold for LAn synaptic potentiation was considerably lowered after extinction, and renewal occluded this low-threshold potentiation. The low-threshold potentiation (a potential cellular substrate for renewal), but not long-term potentiation, was attenuated by dialysis into LAn neurons of a GluA1-derived peptide that competes with Ser831-phosphorylated GluA1. Microinjections of the same peptide into the LAn attenuated fear renewal, but not fear learning. Our findings suggest that GluA1 phosphorylation constitutes a promising target for clinical treatment of aberrant fear-related disorders.-
dc.publisherNature neuroscience-
dc.titleGluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal-
dc.typeArticle-
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