Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials

Title
Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials
Authors
Hee-Kyung NaMi-Hee KimJieon LeeYoung-Kwan KimHongje Jang이경은Hyerim ParkWon Do Heo전혜성Insung S. ChoiYounghoon LeeDal-Hee Min
Issue Date
2013-02
Publisher
Nanoscale
Citation
VOL 5, NO 4, 1669-1677
Abstract
To date, graphene oxide (GO), an oxidized version of graphene, has been utilized in many research areas including bioapplications such as drug delivery and bioanalysis. Unlike other spherical or polygonal nanomaterials, GO exhibits a sheet-like structure, which in itself suggests interesting applications based on its shape. Here we show that GO can protect cells from internalization of toxic hydrophobic molecules, nanoparticles, and nucleic acids such as siRNA and plasmid DNA by interacting with cell surface lipid bilayers without noticeably reducing cell viability. Furthermore, the cytoprotective effect of GO against the internalization of extracellular materials enabled spatial control over gene transfection through region-selective gene delivery only into GO-untreated cells, and not into the GO-treated cells.
URI
http://pubs.kist.re.kr/handle/201004/46916
ISSN
20403364
Appears in Collections:
KIST Publication > Article
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