Various size of magnetic nanoparticles influences cellular uptake in primary Schwann cells

Various size of magnetic nanoparticles influences cellular uptake in primary Schwann cells
Schwann cells; Magnetic nanoparticles(MNPs); Cellular uptake; Nerve regeneration
Issue Date
6th International IEEE EMBS Conference on Neural Engineering
Schwann cells (SCs) are the glial cells of peripheral nervous system (PNS) which myelinate for axons. Functions of SCs are important for proper development, homeostasis, and regeneration of the PNS. In this context, the key is the development of methods to purification primary SCs for nerve regeneration. During the past decade, for biomedical applications, the effect of magnetic nanoparticles (MNPs) has increased considerably. MNPs were used to apply many diagnostic tools for contrast agents in MR (magnetic resonance) imaging or magnetic vectors for drug delivery. MNPs have potential which controlling the directional movement of MNPs and ability to deliver chemicals or biomolecules by an external magnetic field. It proposes that MNPs could be exploited to accelerate nerve regeneration and to provide guidance for regenerating axons. MNPs could create mechanical tension that stimulates the growth and elongation of axons. Little is known about the uptake of nanoparticles in primary cells. Previously studies mostly reported cellular uptake in cell lines. In this study, we present the uptake of 100, 150 and 200nm MNPs by primary SCs. It looks forward to optimize cell labeling and promote nerve regeneration.
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