Surface Modification of Stainless Steel by Introduction of Various Hydroxyl Groups for Biodegradable PCL Polymer Grafting
- Surface Modification of Stainless Steel by Introduction of Various Hydroxyl Groups for Biodegradable PCL Polymer Grafting
- 이유진; 윙 부 배쉬; 박방주; 정윤기; 한동근
- stent; stainless steel; surface modification; hydroxylation; biodegradable polymer grafting
- Issue Date
- Biomaterials Research; 생체재료학회지
- VOL 17, NO 4, 176-180
- The metallic (stainless steel; SS) biomaterials have been utilized for vascular interventional devices such as stents and vena cava filters. However, thrombosis, inflammation, and restenosis that are associated with implants are still major obstacles for the use of these devices. To improve biocompatibility of SS metal, biodegradable poly(ε-caprolactone) (PCL) polymer-grafted SS plates were investigated by surface-initiated ring-opening polymerization (SI-ROP) of ε-caprolactone.
For SI-ROP, surface-functionalized SS was prepared with different hydroxyl derivatives such as L-lactic acid (L), L-serine (S), and ricinoleic acid (RA). The physicochemical properties of surface-modified SS were evaluated. Obtained results exhibited that the surface morphology and properties of SS plates were depending on hydroxyl derivatives as well as the degree of polymerization and polymer grafting density. In particular, RA-coupled SS was greatly attributed to increased PCL grafting to the surface and therefore, this biodegradable PCL-grafted SS is expected to be useful for surface-modified implants including stents.
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