Overview of current standpoints in profiling of circulating tumor cells

Title
Overview of current standpoints in profiling of circulating tumor cells
Authors
Kyobum Kim이관희Jongmin LeeJonghoon Choi
Keywords
Circulating tumor cell; profiling; nanotechnology; cell characterization
Issue Date
2014-01
Publisher
Archives of pharmacal research
Citation
VOL 37, NO 1, 88-95
Abstract
The goal of this review is summarizing current technologies developed as the in vitro prognostic/diagnostic systems that can rapidly separate and detect circulating tumor cells (CTCs) from cancer patient’s blood (1–10 CTCs of 1 billion red blood cells) by labeled and non-labeled method. The review is focused on three major areas of CTC research (1) Summary of previous research on capturing of CTCs, (2) New development of the in vitro prognostic diagnosis system of cancer that is capable of rapid separation of CTCs, (3) Future direction on development of new technologies for CTC profiling. Current CTC researches have helped on identifying patients who may benefit from chemotherapy before treatment, patients who may benefit from continued chemotherapy, and leading to clinical development of CTC-guided chemotherapy strategies. We analyze the feasibility of clinical application of these current CTC research for the ultimate goal of increasing the survivability of cancer patient. The biomolecular assays of viable CTCs from cancer patient may elucidate the mechanism of metastasis and tumor initiating cells and also may have high impact on the development of personalized medicine to overcome the incurable diseases.
URI
http://pubs.kist.re.kr/handle/201004/47090
ISSN
02536269
Appears in Collections:
KIST Publication > Article
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