Association between urinary levels of bisphenol-A and estrogen metabolism in Korean adults

Title
Association between urinary levels of bisphenol-A and estrogen metabolism in Korean adults
Authors
김은지이동호정봉철표희수이정애
Keywords
Bisphenol-A; Steroid hormone; Estrogen metabolism; Hydroxylase; Urine
Issue Date
2014-02
Publisher
The Science of the total environment
Citation
VOL 470, 1401-1407
Abstract
Bisphenol-A (BPA) possesses estrogenic properties both in vitro and in vivo as an endocrine disrupting chemical. Humans experience a long-term and cumulative exposure to BPA. BPA was detectable in 97.3% of 1904 urine specimens from Korean adults. We investigated urinary estrogen concentrations in subjects with low and high BPA concentrations and its possible association with estrogen metabolism. Urine samples were collected from a high BPA concentration group (BPA-H; n = 100, 11.05 ± 20.47 μg/g creatinine) and a low BPA concentration group (BPA-L; n = 100, 0.70 ± 0.22 μg/g creatinine) from Korea Biomonitoring Program of Hazardous Materials Survey 2009.2010. Urinary estrogens were enzymatically hydrolyzed, extracted, and then derivatized for quantitative analysis by gas chromatography.mass spectrometry. Estrogen levels were higher in the BPA-H group than in the BPA-L group. Concentrations of estrone, 17β-estradiol, and their hydroxylated metabolites in both men and women were significantly higher in the BPA-H group than in the BPA-L group (p b 0.04). Furthermore, in the BPA-H group, estrogen metabolism to 4-hydroxy-estrone and 4-hydroxy-17β-estradiol was more active than that to 2-hydroxy-estrone and 2-hydroxy-17β-estradiol. Although single measurement and/or single spot urine samples limit the measurement of long-term exposure to BPA, we found significant differences of estrogenmetabolismin the BPA-H and the BPA-L groups. The increase of hydroxyestrogens, especially 4-hydroxyestrogens, can be an important factor resulting negative effects of prolonged exposure to BPA.
URI
http://pubs.kist.re.kr/handle/201004/47103
ISSN
00489697
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KIST Publication > Article
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