Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems

Title
Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems
Authors
Sungmin Hong정영미Ringo TenHon Fai ChanKam LeongGeorge A. TruskeyXuanhe Zhao
Issue Date
2014-02
Publisher
Lab on a chip
Citation
VOL 14, NO 3, 514-521
Abstract
We developed a microfluidic flow-control system capable of dynamically generating various flow patterns on demand. The flow-control system is based on novel magnetoactive sponges embedded in microfluidic flow channels. Applying a non-uniform magnetic field compresses the magnetoactive sponge, significantly reducing porosity and hydraulic conductivity. Tuning the applied magnetic field can dynamically vary the flow rate in the microfluidic channel. Pulsatile and physiological flow patterns with frequency between 1 and 3 Hz, flow rates between 0.5 and 10 μL min−1 and duration over 3 weeks have been achieved. Smooth muscle cells in engineered blood vessels perfused for 7 days aligned perpendicular to the flow direction under pulsatile but not steady flow, similar to the in vivo orientation. Owing to its various advantages over traditional flow-control methods, the new system potentially has important applications in microfluidic-based microphysiological systems to simulate the physiological nature of blood flow.
URI
http://pubs.kist.re.kr/handle/201004/47130
ISSN
14730197
Appears in Collections:
KIST Publication > Article
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