Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing

Title
Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing
Authors
George A TruskeyHardean E AchneckNenad BursacHon Fai ChanCindy S ChengCristina FernandezSungmin Hong정영미Tim KovesWilliam E KrausKam LeongLauran MaddenWilliam M ReichertXuanhe Zhao
Keywords
microphysiological system; skeletal muscle myoblasts; tissue-engineered blood vessel; contractile force; oxygen gradients; diff erentiation
Issue Date
2013-12
Publisher
Stem cell research & therapy
Citation
VOL 4, S10-1-S10-5
Abstract
Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of diff erent microphysiological organs and their fl ow rates are scaled in proportion to in vivo values. We have developed a microphysiological three-dimensional engineered human skeletal muscle system connected to a circulatory system that consists of a tissueengineered blood vessel as part of a high-pressure arterial system. The engineered human skeletal muscle tissue reproduces key mechanical behaviors of skeletal muscle in vivo. Pulsatile fl ow is produced using a novel computer-controlled magnetically activated ferrogel. The system is versatile and the muscle unit can be integrated with other organ systems. Periodic monitoring of biomechanical function provides a noninvasive assessment of the health of the tissue and a way to measure the response to drugs and toxins.
URI
http://pubs.kist.re.kr/handle/201004/47131
ISSN
17576512
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KIST Publication > Article
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