Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery

Title
Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery
Authors
박주환조현종윤홍열윤인수고승학심재성조지현박재형김광명권익찬김대덕
Keywords
Doxorubicin; Hyaluronic acid-ceramide; Hybrid nanostructure; Lipid; Magnetic resonance imaging
Issue Date
2014-01
Publisher
Journal of controlled release
Citation
VOL 174, 98-108
Abstract
Nanohybrid liposomes coated with amphiphilic hyaluronic acid–ceramide (HACE) was fabricated for targeted delivery of anticancer drug and in vivo cancer imaging. Nanohybrid liposomes including doxorubicin (DOX) and Magnevist, a contrast agent for magnetic resonance (MR) imaging, with 120–130 nm mean diameter and a narrowsize distribution were developed. DOX release from the developed formulation was improved at acidic pH (pH 5.5 and 6.8) versus physiological pH (pH 7.4). Cytotoxicity induced by the blank plain liposome was reduced by coating the outer surface of the nanohybrid liposome with HACE. Cellular uptake of DOX from the nanohybrid liposome was enhanced by HA and CD44 receptor interaction, versus the plain liposome. In vivo contrast-enhancing effects revealed that the nanohybrid liposome can be used as a tumor targeting MR imaging probe for cancer diagnosis. In a pharmacokinetic study in rats, in vivo clearance ofDOX was decreased in the order DOX solution, plain liposome (F2), and nanohybrid liposome (F3), indicating prolonged circulation of the drug in the blood stream and improved therapeutic efficacy of the nanohybrid liposome (F3). Based on these findings, the nanohybrid liposomal system may be a useful candidate for real-time cancer diagnosis and therapy.
URI
http://pubs.kist.re.kr/handle/201004/47259
ISSN
01683659
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KIST Publication > Article
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