Immune-stimulating Effects of Polygonum aviculare L. Extract on Macrophages

Title
Immune-stimulating Effects of Polygonum aviculare L. Extract on Macrophages
Authors
전창배김영훈Dulamjav BatsurenJigjidsuren Tunsag노주원판철호이재권
Keywords
Polygonum aviculare L.; macophage; cytokine; inflammation
Issue Date
2013-12
Publisher
약학회지
Citation
VOL 57, NO 6, 394-399
Abstract
In this study we demonstrated whether the extract of Polygonum aviculare L. (PAE) can be applied to the immune-stimulating responses in macrophages (Raw 264.7 cells). Cell viability was determined by WST-8 assay, and all four doses of PAE (5, 10, 20, and 40 μg/ml) had no significant cytotoxicity during the entire experimental period. PAE increased the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO), and mRNA expressions and protein levels of pro-inflammatory cytokines(tumor necrotic factor (TNF)-α, interleukin (IL)-1β and IL-6) in the same cells. These immune-stimulating activities of PAE were found to be caused by the stimulation of NFκB signal and phosphorylation of MAP kinases (p38, ERK and JNK).
URI
http://pubs.kist.re.kr/handle/201004/47304
ISSN
03779556
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE