Hydroxycinnamic acids in Crepidiastrum denticulatum protect oxidative stress-induced retinal damage
- Hydroxycinnamic acids in Crepidiastrum denticulatum protect oxidative stress-induced retinal damage
- 안홍열; 이희주; 김경아; Kim Chul Young; 노주원; 장호림; 판철호; Lee Chang Yong; 정상훈
- Crepidiastrum denticulatum; chicoric acid; glaucoma; neuroprotection; RGC-5
- Issue Date
- Journal of agricultural and food chemistry
- VOL 62, NO 6, 1310-1323
- We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma
established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death
caused by ONC. Furthermore, EECD effectively protected against N-methyl-D-aspartate-induced damage to the rat retinas. In
vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic
proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species
production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and
3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies.
Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food.
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