Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration
- Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration
- 장호림; 안홍열; 조형; 김경아; 이은하; Lee Ki Won; 정상훈; Lee Chang Y.
- coffee; chlorogenic acid; neuroprotection; retinal degeneration; hypoxia; RGC-5; glaucoma
- Issue Date
- Journal of agricultural and food chemistry
- VOL 62, NO 1, 182-191
- This study explored whether chlorogenic acid (CGA) and coffee have protective effects against retinal
degeneration. Under hypoxic conditions, the viability of transformed retinal ganglion (RGC-5) cells was significantly reduced by
treatment with the nitric oxide (NO) donor S-nitroso-N-acetylpenicillamine (SNAP). However, pretreatment with CGA
attenuated cell death in a concentration-dependent manner. In addition, CGA prevented the up-regulation of apoptotic proteins
such as Bad and cleaved caspase-3. Similar beneficial effects of both CGA and coffee extracts were observed in mice that had
undergone an optic nerve crush (ONC) procedure. CGA and coffee extract reduced cell death by preventing the downregulation
of Thy-1. Our in vitro and in vivo studies demonstrated that coffee and its major component, CGA, significantly reduce apoptosis of retinal cells induced by hypoxia and NO, and that coffee consumption may help in preventing retinal degeneration.
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