Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration

Title
Chlorogenic acid and coffee prevent hypoxia-induced retinal degeneration
Authors
장호림안홍열조형김경아이은하Lee Ki Won정상훈Lee Chang Y.
Keywords
coffee; chlorogenic acid; neuroprotection; retinal degeneration; hypoxia; RGC-5; glaucoma
Issue Date
2014-01
Publisher
Journal of agricultural and food chemistry
Citation
VOL 62, NO 1, 182-191
Abstract
This study explored whether chlorogenic acid (CGA) and coffee have protective effects against retinal degeneration. Under hypoxic conditions, the viability of transformed retinal ganglion (RGC-5) cells was significantly reduced by treatment with the nitric oxide (NO) donor S-nitroso-N-acetylpenicillamine (SNAP). However, pretreatment with CGA attenuated cell death in a concentration-dependent manner. In addition, CGA prevented the up-regulation of apoptotic proteins such as Bad and cleaved caspase-3. Similar beneficial effects of both CGA and coffee extracts were observed in mice that had undergone an optic nerve crush (ONC) procedure. CGA and coffee extract reduced cell death by preventing the downregulation of Thy-1. Our in vitro and in vivo studies demonstrated that coffee and its major component, CGA, significantly reduce apoptosis of retinal cells induced by hypoxia and NO, and that coffee consumption may help in preventing retinal degeneration.
URI
http://pubs.kist.re.kr/handle/201004/47310
ISSN
00218561
Appears in Collections:
KIST Publication > Article
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