Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity

Title
Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity
Authors
Shane A. HeineyJinsook Kim조지어거스틴Javier F. Medina
Keywords
basket cells; disinhibition; eyeblink; forward model; inverse model; molecular layer interneurons
Issue Date
2014-02
Publisher
Journal of neuroscience
Citation
VOL 34, NO 6, 2321-2330
Abstract
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking.Weused an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior.
URI
http://pubs.kist.re.kr/handle/201004/47317
ISSN
02706474
Appears in Collections:
KIST Publication > Article
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