Vertical nanowire probes for intracellular signaling of living cells

Title
Vertical nanowire probes for intracellular signaling of living cells
Authors
이기영김일수김소은정두원김주진임혜원안재평박승한최헌진
Keywords
Silicon nanowire; Intracellular interfacing; Living cell; Nanowire probe; Action potential
Issue Date
2014-02
Publisher
Nanoscale research letters
Citation
VOL 9, 56-1-56-7
Abstract
The single living cell action potential was measured in an intracellular mode by using a vertical nanoelectrode. For intracellular interfacing, Si nanowires were vertically grown in a controlled manner, and optimum conditions, such as diameter, length, and nanowire density, were determined by culturing cells on the nanowires. Vertical nanowire probes were then fabricated with a complimentary metal-oxide-semiconductor (CMOS) process including sequential deposition of the passivation and electrode layers on the nanowires, and a subsequent partial etching process. The fabricated nanowire probes had an approximately 60-nm diameter and were intracellular. These probes interfaced with a GH3 cell and measured the spontaneous action potential. It successfully measured the action potential, which rapidly reached a steady state with average peak amplitude of approximately 10 mV, duration of approximately 140 ms, and period of 0.9 Hz.
URI
http://pubs.kist.re.kr/handle/201004/47371
ISSN
19317573
Appears in Collections:
KIST Publication > Article
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