Lipidomic approach to study metabolic changes in oral administration of rosuvastatin in both healthy human and hypercholesterolemic patients
- Lipidomic approach to study metabolic changes in oral administration of rosuvastatin in both healthy human and hypercholesterolemic patients
- 최종민; 이화정; 정병화
- Lipidomics; Rosuvastatin; Lipids
- Issue Date
- 3rd International Conference and Exhibition on Metabolomics & Systems Biology
- Rosuvastatin is a cholesterol-lowering agent used to treat hypercholesterolemia. It reduces cholesterol level in plasma and affects global lipid metabolism. Therefore, overall change of lipid profile can be closely related to the drug effect or adverse effect. In this study, a simple and rapid lipid profiling method using ultra-performance liquid chromatography quadruple time-of-flight mass spectrometry (UPLC-QTOF-MS) to detect and identify multiple classes of lipids from human plasma was optimized and metabolic change of lipid after rosuvastatin treatment was investigated.
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- KIST Publication > Conference Paper
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