Lipidomic approach to study metabolic changes in oral administration of rosuvastatin in both healthy human and hypercholesterolemic patients

Title
Lipidomic approach to study metabolic changes in oral administration of rosuvastatin in both healthy human and hypercholesterolemic patients
Authors
최종민이화정정병화
Keywords
Lipidomics; Rosuvastatin; Lipids
Issue Date
2014-03
Publisher
3rd International Conference and Exhibition on Metabolomics & Systems Biology
Abstract
Rosuvastatin is a cholesterol-lowering agent used to treat hypercholesterolemia. It reduces cholesterol level in plasma and affects global lipid metabolism. Therefore, overall change of lipid profile can be closely related to the drug effect or adverse effect. In this study, a simple and rapid lipid profiling method using ultra-performance liquid chromatography quadruple time-of-flight mass spectrometry (UPLC-QTOF-MS) to detect and identify multiple classes of lipids from human plasma was optimized and metabolic change of lipid after rosuvastatin treatment was investigated.
URI
http://pubs.kist.re.kr/handle/201004/47411
Appears in Collections:
KIST Publication > Conference Paper
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